entities
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The model estimated symptom onset with a 1.62-year average error in a high-risk research cohort. It is not a clinical test, and its UK Biobank replication relied on approximated dates.
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A longitudinal study of people at elevated genetic risk found a 19-protein panel could estimate when clinical ALS would emerge, but broader validation remains necessary.
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An NIH-funded study of more than 1,200 people found 34 circular RNAs predicted progression better than a leading protein marker, but no clinical assay is yet available.
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A 40-person postmortem study found resident microglia declining from roughly ages 50 to 75, alongside stronger inflammatory signatures—but not proof of dementia causation.
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Seven of nine agencies updated public-access plans, but the watchdog found only NIH had planned for the added publishing expense.
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Recordings from eight epilepsy patients let NIH-funded researchers map language features at single-cell resolution during conversation.
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The CRISPR-engineered mouse colon-cancer model removes B2m and MHC-I antigen presentation to support preclinical research on resistance to PD-1 and PD-L1 therapies.
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The ninth curated release links more than 535,000 whole genomes with nearly 482,000 electronic health records and adds proteomics, RNA and long-read sequencing.
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The international HCMI resource links 665 patient-derived laboratory models with molecular and clinical data for precision-oncology research.
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The prototype platform uses 16,567 CNS reference profiles across 133 diagnostic classes and includes separate kidney-tumor work; commercialization and regulated deployment remain prospective.
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The international resource links patient-derived organoids and other models with molecular and clinical data, including rare cancers and donors of non-European ancestry.
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A molecular atlas of 40 healthy human hippocampi found microglia declined as inflammatory and peripheral-like immune cells became more prominent from about ages 50 to 75.
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The new office will coordinate tissue models, computational tools and other New Approach Methodologies across NIH and with regulators.
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The SenNet papers introduce 'senotypes' to distinguish rare cells by tissue and condition, a step toward studying harmful and beneficial roles without treating them as one group.
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A 1,173-person NIH trial found a 21% lower risk of developing two chronic conditions; metformin did not significantly reduce that outcome.