entities
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An NIH-funded study of more than 1,200 people found 34 circular RNAs predicted progression better than a leading protein marker, but no clinical assay is yet available.
news report
A 40-person postmortem study found resident microglia declining from roughly ages 50 to 75, alongside stronger inflammatory signatures—but not proof of dementia causation.
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A molecular atlas of 40 healthy human hippocampi found microglia declined as inflammatory and peripheral-like immune cells became more prominent from about ages 50 to 75.
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The SenNet papers introduce 'senotypes' to distinguish rare cells by tissue and condition, a step toward studying harmful and beneficial roles without treating them as one group.
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A 1,173-person NIH trial found a 21% lower risk of developing two chronic conditions; metformin did not significantly reduce that outcome.